THE LNCRNA SIGNATURE ASSOCIATED WITH CUPROPTOSIS AS A NOVEL BIOMARKER OF PROGNOSIS IN IMMUNOTHERAPY AND DRUG SCREENING FOR CLEAR CELL RENAL CELL CARCINOMA

Cuproptosis is a new form of cell death, the second form of metal ion-induced cell death defined after ferroptosis.Recently, cuproptosis has been suggested to be associated with tumorigenesis.However, the relationship between cuproptosis and patient prognosis in clear cell renal cell carcinoma (ccRCC) in the context of immunotherapy remains unknown

Based on the analysis of the hydrogeological data of the first mining area in Zhaoxian Coal Mine, by using the research methods of theoretical analysis, similar material test and numerical simulation, the separation layer of overburden strata and water in the mining process of extra-thick coal seam is predicted theoretically.The dynamic development

The advent of multidrug resistance among pathogenic bacteria is devastating the worth of antibiotics and changing the way of their administration, as well as the approach to use new or old drugs.The crisis of antimicrobial resistance is also due to the unavailability of newer drugs, attributable to exigent regulatory requirements and reduced financ

Cannabis sativa is a complex domesticated plant that has an unstable taxonomy.It is the most utilised illicit substance that has gained prominence in some parts of the world as it is used for therapeutic and recreational purposes.C.Sativa has also been used to manage numerous medical SHEARS conditions since antiquity.The pharmacological benefits of

Abstract Significant efforts have been devoted to investigating the oxidation of MXenes in various environments.However, the underlying mechanism of MXene oxidation and its dependence on the electrode potential remain poorly understood.Here we show the oxidation behavior of MXenes under the working conditions of electrochemical processes in terms o